Press Releases
For Immediate Release
December 19, 2006
Contact:
Carolyn Hawley
Canale Communications for Orion Genomics
619-849-5375
carolyn@canalecomm.com
Orion Genomics Announces the Validation of Novel Breast Cancer Biomarkers
ST. LOUIS, MO - December 19, 2006 - Orion Genomics announced today that the company has identified and validated a suite of novel breast cancer biomarkers, the most promising of which will be incorporated into the company's diagnostic assays for the early detection of breast cancer and the detection of breast cancer recurrence. Using proprietary genome-wide microarray technology, the company was able to quickly identify a suite of novel biomarkers in a panel consisting of normal and cancerous breast tissues. In a second independent biomarker validation panel of more than 200 normal and cancerous breast tissues, over 50 biomarkers demonstrated significant diagnostic potential, the most promising of which presented 90 percent sensitivity and 96 percent specificity. The results of Orion's genome-wide DNA methylation profiling were presented at the 29th Annual San Antonio Breast Cancer Symposium on December 14, 2006 in San Antonio, Texas.
"Utilizing MethylScope®, our genome-wide DNA methylation profiling technology, we were able to quickly identify a suite of promising breast cancer biomarkers that show significantly high sensitivity and specificity and represent the most comprehensive and clinically accurate breast cancer epigenetic biomarkers discovered to date," said Jorge A. Leon, Ph.D., Orion's acting Chief Scientific Officer. "We are now validating our most promising biomarkers in blood serum from cancer-free and breast cancer patients."
"Identifying cancer earlier in the disease progression timeline will significantly improve treatment outcomes and patient survival, especially in breast cancer," said Nathan Lakey, Chief Executive Officer and president of Orion Genomics. "Our identification and validation of sensitive and specific biomarkers for the detection of breast cancer will form the foundation of our breast cancer diagnostic assays. These assays will provide a diagnostic screening test, from blood or other easily collected samples, of a large population for the early or recurrent signs of breast cancer."
About Orion Genomics
Orion Genomics, the Second Code Company, develops epigenetic research tools and molecular diagnostic products to fulfill the promise of personalized medicine. Orion's lead product is a simple blood-based test that is being developed to identify people at elevated risk for colorectal cancer. The company has active biomarker discovery programs in cancers of the bladder, breast, lung, ovaries and colon, and the company offers genomics services to the medical, agricultural and bio-fuels research communities. Orion Genomics is located in the Center for Emerging Technologies in St. Louis. For more information, visit the Orion Genomics website at http://www.oriongenomics.com.